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[Abstract] Compared with guinea pigs receiving periocular injections of vehicle (5 mM, 10 L on days 1, 4, 7, 10, and 13 over two weeks), those treated with glutathione oxidized (Glu, 20 mg/mL, 10 L on the same schedule) exhibited a 1.76-fold increase in relative myopia, along with a 1.78-fold increase in axial length (AL)
H2S = hydrogen sulfide)
Meanwhile, an enzyme in the human body called glutathione reductase recycles oxidized glutathione back into its reduced state,18 allowing the tripeptide to continue carrying out its biochemical functions
It can also be made in a lab into a dietary supplement, which is used widely in alternative medicine
These results thus suggest that NAPstars report the bona fide NADP redox state rather than responding solely to the NADPH concentration
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